Gene CaMKK2 (Human)

CaMKK2

Species: Human
Alias: CAMKKB, MGC15254, CAMKK2, Hs.197806, CAMKK, CaMKK2, KIAA0787
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q24.31,

Classification

Group: Other
Family: CAMKK
Subfamily: CAMKK-Meta

Sequence

Name Sequence Type Origin Length Description Download
CaMKK2.AA Protein Sugen Kinome 588 None Fasta, JSON
CaMKK2.kin_dom Protein Kinase Domain Sugen Kinome 282 None Fasta, JSON
CaMKK2.NA RNA Sugen Kinome 5620 None Fasta, JSON

Protein domain

Protein domains of CaMKK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CaMKK2.AA Meta 165-446 73 9.5e-276 806.11 In-house 1-287 (287) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-287/287
Sequence Identity: 73% (212 aa)

YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLY
|.|..||||||||||||||||.|...||||.||||||..|.||.|||||||..|..|||||||.|...|||||||||||||||||||||||||||||.||
YRLMEEIGKGSYGVVKLAYNEEDHHHYAMKILSKKKLLKQYGFMRRPPPRGNKPNQGGCIQPRNPLDRVYQEIAILKKLDHPNVVKLVEVLDDPNEDYLY

MVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN--TVGTPAFMAPESLSET
||||.|..|||||||...|||||||..||.|...|.|||||||||||||||||||...|||.|||||||||||.|.||.|.|  |.|||||||||..||.
MVFEYVEKGPVMEVPCDNPLSEDQAWSYFRDIVCGLEYLHYQKIIHRDIKPSNLLLNDDGHVKIADFGVSNEFEGDDAFLCNGSTAGTPAFMAPEACSEE

RKI-FSGKALDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV
... ..|.|||||||||||||||||||||.|  ..|||||.|||.....||.||.|.|||||.|.||||||||.||..||||.||||
QNHFYCGRALDVWAMGVTLYCFVFGQCPFIDKTNYIMCLHDKIKNHPVMFPEQPEISEDLKDCIKRMLDKNPEHRIMIPEIKTHPWV
Kinase CaMKK2.AA CAMKK 165-446 42 2.9e-194 622.51 In-house 1-396 (396) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-396/396
Sequence Identity: 42% (167 aa)

YTLKDEIGKGSYGVVKLAYNEND-NTYYAMKVLSK----KKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPN
|.|..|||.|..|.|||||||.| ...||.|...|    |||.....|.|.||.|.|.....|..|.. |...|||||||.||..|||.|||.||.|||.
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

EDHLYMV-FELVNQGPVMEVPTLKP--------------------------LSEDQ---------------------ARFYFQDLIKGIEYLH-YQK---
.|..||| .|....|..|..|. |.                          .||.|                     |. ||.| |||.|||| |||   
NDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACS

----------------IIHRDIKPSNLLVGEDG---HIKIADFGVSNEFKGSDALLSN-----------TVGTPAFMAPESLSE-TRKI-----------
                ||||||||.|.|..|.|   |.||||||||..|.|.|..|||           |.|||||||||..|.   |            
YIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRF

-FSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS---KIKSQALEFPD-----------QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV
 ..|||.|.||.||||||||||.|||... .|.||    ||| . ..||.           .|.| |||||||.|||.|||. || .|.|| ||||
IYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase CaMKK2.AA S_TKc 165-446 29 7.6e-95 322.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-231/231
Sequence Identity: 29% (87 aa)

YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLY
|.. ..||||..|.|..... ... ..|.|...                                 |....||.|||| .|||.||| .| .|   ||||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLY

MVFELVNQ--GPVMEVPTLKP-------LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMA
||.|....  | ....   ..       ..| .||||.. .....||.| ..|||||.||.|.|. |  ||||.|||.. ..       .  .||| .||
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMA

PESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKL-------HPWV
|| |      ..... |.|. |..|| .. |. ||    .. .  ||.             ...||.| ..|.|.|| |. . |.         |||.
PEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CaMKK2.AA AGC 165-446 23 2.4e-92 238.38 In-house 1-395 (395) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-395/395
Sequence Identity: 23% (101 aa)

YTLKDEIGKGSYGVVKLAYNE------NDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRG--PIEQVYQE------------IAILKKLD
. ..  |||||.| | |.           . |||||||.||.                       |. .    .|... |              ||.|..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKH----------------------KIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCN

----------HPNVVK-LVEVLDDPNEDHLYMVFELVN--------QGPVMEVPTLK------PLSEDQARFYFQD-------LIKGIEYLHY-QKIIHR
          ||..|| |     |.. ..||.| |...         |  .    |.       ..|..||||.         .. ..||||  ..||||
HTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHR

D-IKPSNLLVGEDGHIKIADFGVSNEFKGSD--------------------------------------------------ALLSNTVG--TPAFMAPES
| .|| |.|  ||||||..||| . |.....                                                  .. .  .|  || .|||| 
DYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEI

LSETRKIFSGKALDVWA--MGVTLYCFVFGQCPFMDER----------IMCLHSKIK------SQALEFP--------DQPDIAEDLKDLITRMLDKNPE
|        ||| | |.  .|. .| ...|. || ..            | .. ||.      .. ..||        ... . ...||||...| |.||
L-------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPE

SRIV----------VPEIKLHPWV
 |.           . ||| ||| 
KRLGCGGNDFGDKGAEEIKNHPWF
Kinase CaMKK2.AA CAMKL 165-446 30 8.6e-90 286.72 In-house 1-297 (297) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-297/297
Sequence Identity: 30% (98 aa)

YTLKDEIGKGSYGVVKLAYN-ENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQ-------VYQEIAILKKLD---HPNVVKLVE
|.. ...||||.|.|||| .  . .. .|.|.. |||.       .....                  |       ...||.|.|.|.   |||..|| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCG------------------QKHESDMRIRREIQIMKMLNIGKHPNIIKLYE

VLDDPNE----DHLYMVFELVNQGP--VMEVPTLKP-----LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDG--HIKIADFGVSNEFK-G
|...|.     ...|.| |..  |    ..    ..     ..|..||.||. .. ...|.| ..|.|||||| |.|. |.|   |||.||| ||... .
VIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC

---SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE--------RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLD
   .. .|.   |.|..|||| .. . | . |.. |.|..||.||  |.|. || |.         |  |. ||...  ..|  ...  |..||| .|| 
IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQ

KNPESRIVVPEIKLHPWV
.||| |. . .|. |||.
VNPEKRPTIHQIMNHPWM
Kinase CaMKK2.AA CAMK 170-446 22 5.8e-89 286.74 In-house 1-425 (425) Show / Hide 
Range on Protein: 170-446
Range on HMM: 1-425/425
Sequence Identity: 22% (99 aa)

EIGKGSYGVVKLAYNENDN------------TYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQ-------------PRGPIEQVYQEIAILKK--
..|.||.|.|||... |..            . .|.|...||||  .       .          |..                  ..|..||.|.||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDY-S-N--------CYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQ

-----LDHPNVVKLVEVLDDPN-----------------EDHLYMVF---ELVNQG----PVMEVPTLK----------------PLSEDQARFYFQDLI
     |||||..|| || .||.                 ..|.|||.   |..  |     . .  . .                 ..|..||.||. ..
GIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQIC

KGIEYLHYQKIIHRDIKPSNLLVGED-----------------GHIKIADFGVSNEFKGS-----------------------DALLSNTVGTPAFMA-P
 ...|.| ..|.|||.|| |.|. ..                 . |||.||| .|.|...                       . ...  .|||..|| |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

ESLSETR-----------KIFSGKALDVWAMGVTLYCFVFGQCPFMDE-------------RIMCLHSKIKSQALEFPD--------------QPDIAED
| |.  .           |   |.. |.|..|| ||  . |  || ..              .  |. ||..   .||.                || ..
EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE

--------LKDLITRMLDKNPESRIVVPEIKLHPWV
         |||| .|| ..|| |. . ... |||.
FHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CaMKK2.AA Pkinase 165-446 26 4e-81 280.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-293/293
Sequence Identity: 26% (86 aa)

YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAG-----FPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPN
|...  ||.||.|.|..... ...  .|.|...|..   .                                   .||.|.|.|.|||.|.| ..  |  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---------------------------SEIQIMKRLNHPNIVRLYDWFED--

EDHLYMVFELVNQG----PVMEVPT---LKPL--SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHI----KIADFGVSNEF-KGSDALLS
.||.|||.|... |      ... .    ...  ||....||.  ...|.||.| ..|||||.||.|.|. ..|||    ||.|||..  |   ..  ..
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT

NTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE------RIMCLHSKIKSQALEFPDQPDIA-------------------EDLK
  .||| .|||| .        |.. |.|..|..||....|. || ..      . | .. .|..  |.|. . ..                    |..|
TFCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

DLITRMLDKNPESRIVVPEIKLHPWV
|.|...|.|.|..|.  ..|. |||.
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CaMKK2.AA Ciliate-E2-Unclassified 165-446 25 2.4e-69 236.7 In-house 1-352 (352) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-352/352
Sequence Identity: 25% (96 aa)

YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS-----KKKLIRQ--------------------AGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAI
|..   ||.|..|.|......... ||||| ..     |.|.|..                                             ...  |.  |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRK------------------------YNKIMQQ--I

LKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL------------------KPLSEDQAR-----FYFQDLIKGIEYLHYQK-IIHRDIKP
|. ..||..||....  |  ....|.| |....|  ..  .                   | ..| ||.     |||  ...|.||||... ||||||||
LLNHPHPFIVKMFYCFQD--KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP

SNLLVGEDG---HIKIADFGVSNEFKGS---------------DALLSNTVGTPAFM----APESLSETRKIFSG---KALDVWAMGVTLYCFVFGQCPF
.|.|. ..|   .|||.||| | . . .               . ... ..||| .|    ||| |   ..  ..   .. |.|..|| ||...||..||
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL--QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF

MDER-----------IMC------LHSKIKSQALEFPDQP------DIAEDLKDLIT----RMLDKNPESRIVVPEIKLHPWV
 |.            | .      |...|| . ..|| .|      .. .  ||.|.    .||.|||..||  ..|. ||| 
YDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CaMKK2.AA Ciliate-E2 165-446 22 2.8e-69 236.48 In-house 1-365 (365) Show / Hide 
Range on Protein: 165-446
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQ-------------PRGPIEQVYQEIAILK----------
| .   ||.|..|.|... . ...  .|.|.   .|..||                    |                 |||. ||| |..          
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQ------------------MQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKIN

------KLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--------------VPTLKPLSEDQARFYFQDLIK---------------GIEYLHYQ
      .|.|||..|..|.  . .....|.|.|....|  ..                  |...| ....... ...               ..|||| .
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK

K-IIHRDIKPSNLLVGEDGHIKIADFGVS----------------NEFKGSD----------------ALLSNTVGTPAFMAPESLSETR------KIFS
. ||||||||.|.|.     |||.||| |                ....                    .  ...||| .|||| |.         .   
NNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGY

GKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFP----------------DQPDIAEDLKDLITR----MLDKNPESRIV-VPEIKLHPWV
... |.|..||.||...||. ||          .|| . ..||                .  .. .. |||| .    ||.|.|| ||    .|. ||| 
DYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CaMKK2.AA CAMKK-Unclassified 282-446 28 6.5e-63 203.69 In-house 173-392 (392) Show / Hide 
Range on Protein: 282-446
Range on HMM: 173-392/392
Sequence Identity: 28% (63 aa)

KPLSEDQARFYFQDLIKGIEYLHYQK---------------------IIHRDIKPSNLLVGEDGH-----IKIADFGVSNEFKGSDAL-LSNTVGTPAFM
. ..|.... ||.. .||. |.| ..                     |||||||| |.| ....      .||||||.|  .....   |.|. ||..||
YKMHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFM

APESLSETRKIFSGKA-------------------------LDVWAMGVTLYCFVFGQCPFMDERIMCLHS-KIKSQALEFPD--QPDIAEDLKDLITRM
|||..|   .   ...                          |.|. |||.||.|..  ||  .  . |   .|.   . ||   .|.. . .||||..|
APEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCSHEFKDLIQKM

LDKNPESRIVVPEIKLHPWV
.||||. || .  .  |||.
CDKNPKKRITIDQMLVHPWF
Kinase CaMKK2.AA ULK 230-446 30 1.8e-62 213.89 In-house 54-329 (329) Show / Hide 
Range on Protein: 230-446
Range on HMM: 54-329/329
Sequence Identity: 30% (84 aa)

IEQVYQEIAILKKLD--------HPNVVKLVEVLDDPNEDHLYMVFELVNQG----------PVMEVPTL--KPLSEDQARFYFQDLIKGIEYLHYQKII
.... .|| |.|||.        |||.||| ... ..|....|...|. |.|          . .|   .  | |||..|. .|.... |  .|| ..||
WQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDT-EEKKRLSEQEAIQFFKQILNGFKELHKHNII

HRDIKPSNLLVGED------------GHIKIADFGVSNEFKGS---DALLSNTV------GTPAFMAPESLSET--RKIFSGKALDVWAMGVTLYCFVFG
||||||.| |. ..            |..|||||| .  .  .   ....  .|      ||| .|||. |..   .| .. .  |.| .|. .|  ..|
HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG

QCP----FMDER---IMCLHSK-------IKSQALEFP---DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV
..|    |.|.    |. |  .       ||.| |.||   ..| | ...|||| ||| .... ||  .|.  |||.
KPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CaMKK2.AA ULK 230-446 30 9.9e-61 208.07 In-house 54-324 (324) Show / Hide 
Range on Protein: 230-446
Range on HMM: 54-324/324
Sequence Identity: 30% (84 aa)

IEQVYQEIAILKKLD---HPN--VVKLVEVLDDPNEDHLYMVFELVNQG----------PVMEVPTL--KPLSEDQARFYFQDLIKGIEYLHYQKIIHRD
...  .|| |.|||.   |||  .||| ... ..|....|...|. |.|          . .|   .  | |||..|. .|.... |  .|| ..|||||
WQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-T-EEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRD

IKPSNLLVGED------------GHIKIADFGVSNEFKGSD---ALLSNTV------GTPAFMAPESLSET--RKIFSGKALDVWAMGVTLYCFVFGQCP
|||.|.|. ..            |..|||||| .  .   .    ..  .|      ||| .|||. |..   .| .. .  |.| .|. .|  ..|..|
IKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYP

----FMDER--IMCLHSK-------IKSQALEFP---DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV
    |.|.   |. |  .       || | ..||   ..| | ...|||| ||| .... ||  .||  |||.
FFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase CaMKK2.AA CAMKK-Unclassified 230-277 52 7.9e-18 54.38 In-house 62-111 (392) Show / Hide 
Range on Protein: 230-277
Range on HMM: 62-111/392
Sequence Identity: 52% (26 aa)

IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM--VFELVNQGPVME
.  |.||||| |||.|||..|| || ||| .| .||  | |.. .| .|.
LHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQVMEYCQMGQIMS
Kinase CaMKK2.AA TyrKc 165-440 21 2.8e-15 24.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 165-440
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--DHPNVVKLVEVLDDPNE--
 ||....| | .|.| ..      .  | |.| . .                             .|  ..|. |..||  .|||.|.|. |  .. .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNF

---DHLYMVFELVNQGPVME-VPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS-------DAL-----
   . |..|.|..  |   .     .| |. ..   .  .  .| |||| ...||||.   | ||||....||.||| | . .         |       
MYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-LSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDE--RIMCLHSKIKSQALEF--PDQPDI---------AEDLKDLITRMLD
  ..|.     ||||..    ..|. |  |||. ||...  | .|| |  ..  . |.  . .  .  .   ..||.           ... .....  .
KGGKTMLPIRWMAPECI--NYGKFTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

KNPESR----IVVPEI
 .||.|     .. ..
EDPEDRPTFSEIHECF
Kinase CaMKK2.AA ULK 165-204 36 4.4e-10 32.03 In-house 1-44 (324) Show / Hide 
Range on Protein: 165-204
Range on HMM: 1-44/324
Sequence Identity: 36% (16 aa)

YTLKDEIGKGSYG-VVKLAYNEND---NTYYAMKVLSKKKLIRQ
| |....||||.| .|  ..|...   | |.| |. .|||.. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKK
Kinase CaMKK2.AA ULK 165-204 31 1.2e-09 30.0 In-house 1-44 (329) Show / Hide 
Range on Protein: 165-204
Range on HMM: 1-44/329
Sequence Identity: 31% (14 aa)

YTLKDEIGKGSYGVVKLAYNEND----NTYYAMKVLSKKKLIRQ
| |....||||.|.|  ..|...    | ..| |...|.|....
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQK
Kinase CaMKK2.AA CAMKK-Unclassified 165-201 38 2.6e-08 22.85 In-house 1-42 (392) Show / Hide 
Range on Protein: 165-201
Range on HMM: 1-42/392
Sequence Identity: 38% (16 aa)

YTLKDEIGKGSYGVVKLAYNENDN-----TYYAMKVLSKKKL
|.. |..| ||.| |||| .....     ...| ||  | ||
YEFLDKLGRGSFGKVKLATRRYTTDDGVQKQFAIKVFKKQKL
Kinase CaMKK2.AA Pkinase_Tyr 298-381 33 5e-07 24.42 Pfam 122-205 (270) Show / Hide 
Range on Protein: 298-381
Range on HMM: 122-205/270
Sequence Identity: 33% (29 aa)

KGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEF--KGSD-ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY
|| |||. ...||||.   | ||.|....||.||| .     ..      ...      ||||.... .  |. |  |||. ||...
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKS-DVWSFGVLMW
Kinase CaMKK2.AA Pkinase_Tyr 230-273 33 6.7e-05 17.21 Pfam 47-92 (270) Show / Hide 
Range on Protein: 230-273
Range on HMM: 47-92/270
Sequence Identity: 33% (16 aa)

IEQVYQEIAILKKL-DHPNVVKL---VEVLDDPNEDHLYMVFELVNQG
.|   .|..|.|.| .|||.|.|   .   ..||  ..|.|.|..  |
REDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHG
Kinase CaMKK2.AA Pkinase_Tyr 165-183 26 0.16433 5.74 Pfam 1-19 (270) Show / Hide 
Range on Protein: 165-183
Range on HMM: 1-19/270
Sequence Identity: 26% (5 aa)

YTLKDEIGKGSYGVVKLAY
 |.  ..|.|..|.|....
ITFGKKLGEGAFGEVYKGT